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Fritz Klein was born Fred Klein in Vienna, Austria, to orthodox Jewish parents. He and his family fled to New York when he was a child, to escape anti-semitism. He received a BA from Yeshiva University in 1953, and an MBA from Columbia University in 1955. He studied medicine at Bern University in Switzerland for six years, receiving his MD in 1971.
He practised as a psychiatrist in New York in the 1970s. As a self-identified bisexual, he was surprised at the lack of literature on his sexuality in the New York public library in 1974. He was inspired to place an advertisement in the Village Voice and founded the Bisexual Forum. He devised the Klein Sexual Orientation Grid, a multi-dimensional system for describing complex sexual orientation, similar to the zero-to-six scale Kinsey scale used by Alfred Kinsey, but measuring seven different vectors of sexual orientation and identity (sexual attractions, fantasies, emotional preference, social preference, lifestyle and self-identification) separately, as they relate to a person's past, present and ideal future.
He published The Bisexual Option (1978), based on his research, the worlds first real psychological study of bisexuality. He also co-authored Man, His Body, His Sex (1978), and published Bisexualities: Theory and Research (1986) and Bisexual and Gay Husbands: Their Stories, Their Words (2001). He also published a novel, Life, Sex and the Pursuit of Happiness (2005).
Klein moved to San Diego in 1982, founded a second Bisexual Forum, and founded the Journal of Bisexuality. He remained its editor until his death. He founded the American Institute of Bisexuality (AIB), also known as the Bisexual Foundation, in 1998 to encourage, support and assist research and education about bisexuality.
He was diagnosed with cancer, and underwent surgery as a result. He died following a cardiac arrest, at aged 73. He was survived by his life partner, Tom Reise. He donated his body to science.
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